Successful implementation of computerized provider order entry (CPOE) is foundational to leveraging the value of computerized medical records. When done effectively, CPOE results in improved patient safety, improved quality of care, more predictable therapeutic outcomes and improved efficiency. CPOE is also required to comply with Meaningful Use thresholds, but it's not easy. Engaging clinician participation and adoption can still pose a big challenge. Field and experience-tested tools and methods are available to assist clinical organizations in achieving successful CPOE implementation.