Oplocks On cause issues opening multiple files over WAN
If you run into a situation where your Isilon is located in one city and you have a remote office with a Creative Services group in another city than this article is for you.
Because of the size of the adobe files that where being worked with and the limited 200MB pipe in between the 2 sites when a file copy over SMB 2 was initiated the Creative Services workstation basically locked up until that file transfer was done. This caused major headaches for the creative services crew as they where working with files that could be multiple gigs in size and during the transfers they were losing out on productivilty.
Now WAN Optimization would help as well one thing you can do on the Isilon in this situation is to run the following command to see if Oplocks are on.