Why would it be an issue, you are swapping a 2.5" SATA HDD with a 2.5" SATA SSD. Just make sure properly clone the hard drive and re-format the entire HDD after you verify the SSD works okay. We have several people at work who replaced their E6420 with Samsung EVO 500GB SSD. They only rave about how fast their system is now and how they wished they had switched sooner.