Thank you for writing on Dell Community.
I would suggest you to click on the link http://dell.to/1jQ1Bjn and update the BIOS from BIOS Section and Chipset from Chipset Section by selecting the version of Operating System.
Once updated please restart the system and check, If the issue still persists follow the below steps to Run the Dell Diagnostics on USB ports on the system.
1. Open the link http://dell.to/11MXNII
2. Select ‘Hardware’ under ‘Dell PC Diagnostics’.
3. Select ‘USB’ under ‘Diagnostic Selector.
4. Click on ‘Run Diagnostics’ button.
5. Let me know the results.
Please let me know if this helps.
I would suggest you to boot the system in Safe Mode with Networking and check for the USB Issue.
Follow the steps below to boot the system into Safe Mode with Networking :
Let us know your findings
I would suggest you to provide us with the error message that you get.
Also want you to check and confirm if the same USB device (flash drive) is working good on a different system.
Please send me a private message with the computer's service tag, Name registered during the system purchase. To send a private message, click on my name and select send private message.
Let us know your findings.