Upgraded Components and now My operating system isn't supported?

We bought 2 Alienware computers and decided we wanted to upgrade a few things (motherboard/ liquid coolers and fans/case) Now when we try to get our motherboard software to install "this operating system isn't supported''.  It's supposed to be just windows 10. We have verified our copies via all the steps windows provides and we've had nothing but problems after updating.  Does Dell make a **bleep** copy for alienware products that's made not to work with any other upgrades/components? It sure seems like it. The only thing we kept with our SSD, the rest was supposedly us starting fresh when we got the new motherboard. Any help getting this corrected without spending even MORE to get a completely new windows 10 would be greatly appreciated.