Re: I have an Alienware 17 R4. Does it have Pcie interface to use the newest generation pcie ssd's???
If you have no other drives in the system, then yes generally should only have to physically install the drive and the machine will see it and present it to the operating system. If you will have additional drives in the system, you'll need to enter the BIOS and make sure the NVMe stick is the first boot option if you want to install Windows there and have it be your primary system drive.
Also make sure your controller is in AHCI mode in the BIOS, unless you specifically need/want to create a RAID array.
You'll also need to install the Samsung NVMe driver (available from their website) after Windows installation is complete. The Magician software is optional but useful.
Performance wise, going from SATA SSD to NVMe SSD is a much smaller jump than a spinning disk drive to a SATA SSD, but it is noticeable to me and definitely impressively fast.