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Dimension E521 RAM upgrade

I decided to upgrade RAM from 2000MB to 3000. I just ordered a 1000 MB module from  Dell intending to install it in DIMM 3. However, I just noticed that it is suggested that these modules be installed in pairs of two. Is it OK to install just the one in DIMM 3? Will this adversely affect performance? Caught me by surprise. Hope you can help. thanks.

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