Re: How do YOU back up your Isilion?
The reason I suggested NFS was simply because that's we use our Isilons for - almost 100% NFS v3 - so an NFS-based backup strategy would catch it. If you're strictly an SMB shop, backing up via NFS would be pretty foolish as Chris pointed out. If you're 100% SMB, then backing via SMB shares might be an option.
I still prefer SyncIQ for our environment simply because it's not practical to walk petabyte file systems. That's also how I found a few SyncIQ bugs