Without any advanced setup and plug'n'play technology, the Adesso iMouse E3 USB Vertical Right-handed Ergonomic Mouse provides you with comfort as it conforms to your hand's natural positioning and relief as you feel less strain on your wrist and finger joints. This ergonomic mouse is designed with a vertical orientation and a contoured shape that provides a uniquely comfortable user experience. With this wrist-friendly contour support, you will hold your hand in a healthy "handshake position" which is the neutral position of your forearm as opposed to the "twisted forearm" position as with a regular mouse. Two internet buttons are conveniently located on the side of the mouse for Back and Forward page browsing. The switchable DPI button on the top, provides multiple DPI levels of mouse cursor speed that is useful in different environments. The advanced Optical Sensor technology keeps the mouse precisely on point and lets you work on most glass, wood, marble, and leather surfaces without a need of a mouse pad. Be ready to enjoy the freedom of a comfortable, pain free mouse experience!