RP4VM installation multiple ESXi cluster

Hi All,

We're planning to protect VM's spread across 3 different ESXi Cluster managed with 1xVcenter at 1 site to remote site. Could I deploy 2xRP4VM app in One of the ESXi cluster and protect VM's from different ESXi clusters at one site? or do i need to deploy 2xRP4VM app in each of the ESXI cluster where VM to be protected resides?

Appreciate your help.