Encryption can be handled in several ways. Data at rest encryption on Isilon can be handled by buying nodes with SEDs (self encrypting drives). Data at flight encryption can be handled by the protocols in use (SMB 3 or kerberized NFSv4), or by a third party application. One of the best in this area is certainly Vormetric from Thales.

https://www.thalesesecurity.com/solutions/use-case/data-security-and-encryption/database-security/securing-unstructured-files

Hope this helps,

Chris Klosterman

Principal SE, DataDobi

You can also find more in the OneFS Security Configuration Guide that is applicable to your version of OneFS. If you are having trouble finding the guide, let me know what version of OneFS you are working with and I can grab the link for you.