That is interesting. 

If it were me, I would just uninstall and reinstall the Alienware Command Center. It would probably be easier than trying to troubleshoot it from the .Net side.

If the error persists, you can see if Windows Update shows a pending .Net update, or if the problem started when the latest .Net update was pushed out by Windows Update a couple of days ago. If it started with the latest .Net quality update, you can rollback the update.

Do you have alienware hardware installed and the lighting is not working properly? If so, maybe check for a driver update for your mouse / keyboard. 

Or check for corrupted files with the system file checker command (SFC) command scannow 

USB VID_04CA & PID_00A6
Vid : 04CA Pid : XXXX    Lite-On Technology Corp.

 

Install DOT NET 3.5 SP1 full version while online

https://www.microsoft.com/en-us/download/details.aspx?id=25150

 

then run SFC / Scannow

It may already be too late.

How to Run SFC Scannow (SFC.exe)

1. First, you’ll need to boot into your computer with administrative privileges (as I already discussed).
2. Once Windows logs in, press + R, type cmd then press Ctrl + Shift + Enter to open Command Prompt as Administrator. ...
3. When Command Prompt loads up, type the following commands
4. sfc /scannow
5. DISM.exe /Online /Cleanup-image /Restorehealth

 

 

Looks like you were installing this version

<ADMIN NOTE: Broken link has been removed from this post by Dell>

https://dl.dell.com/FOLDER06288681M/1/Alienware-Command-Center-Application_HWJNT_WIN_5.2.89.0_A00.EXE

 

Other fixes may also be needed

1. Uninstall Alienware Command Center from Program and Features
   • Windows 8 / 8.1 / 10: Right-click on the lower left-hand side of the screen
   • Windows 7: Click Start > Control Panel > Programs and features
2. Launch the Run Command
   •  + R on the customer’s keyboard
   • Windows 8 / 8.1 / 10: Right-click on the lower left-hand side of the screen
   • Windows 7: Click Start > Run
3. Type %appdata% and press Enter
4. Delete any Alienware Folder. If the folder is not there just continue.
5. Type %programdata% and press Enter
6. Delete any Alienware Folder. If the folder is not there just continue.
7. Go To C:\Program Files\Alienware\Older versions of command center will be under C:\Program Files (x86), please check both folders.
8. Delete the Command Center Folder Only
9. Go to the Documents Folder (My Documents on Win 7)
10. Delete the AlienFX and Alienware TactX Folders
11. Launch the Run Command
12. Type regedit
13. Search the following registry key: HKEY_LOCAL_MACHINE\SOFTWARE\Alienware
14. Delete the following folders only: (Some of these may not be present, just delete the ones present)
    • AlienFXMediaPlugin
    • Alienware AlienFX
    • CCPlugins
    • Command Center
15. Search the following registry key: HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Alienware
16. Delete the following folders only (Some of these may not be present, just delete the ones present):
    • AlienFXMediaPlugin
    • Alienware AlienFX
    • Command Center
17. Restart the PC
18. Download and install the latest Alienware Command Center version for your unit.

Not all versions are for all models and there is no ONE click One size fits all.

OLDER models CANNOT USE the newest version

It’s worth noting that there may be additional modules of the software that you need to download to have the full functionality. One such module is the OC Controls software. If it still doesn’t work, you may have issues related to Microsoft Visual C++ runtime components.

 

 

Alienware Gaming Peripheral driver
This package contains software component that enables the Alienware peripherals in Alienware Command Center 5.2 and later versions. Alienware Command Center runs on Windows 10 operating system build 1709 and later.
AW959 Elite Gaming Mouse
AW958 Elite Gaming Mouse
AW768 Pro Gaming Keyboard
AW568 Advanced Gaming Keyboard
AW558 Advanced Gaming Mouse
8/3/18

AW958 Elite Gaming Mouse
AW568 Advanced Gaming Keyboard
AW558 Advanced Gaming Mouse
8/30/17

Windows Store Alienware Command Center
Quick Guide
15 R3/R4, 17-R4/R5, Alienware or Dell Gaming Device
7/31/18

5.2.37.0 <ADMIN NOTE: Broken link has been removed from this post by Dell>

15 R4, 17 R5, m15, m17, Area-51m, Alienware or Dell Gaming Device
5/21/19

5.2.29.0 <ADMIN NOTE: Broken link has been removed from this post by Dell>

15 R4, 17 R5, m15, m17, Area-51m, Keyboard AW568/AW768, Mouse AW558/AW958/AW959/AW988
3/25/19

5.2.24.0
15 R4, 17 R5, m15, m17, Area-51m, Keyboard AW568/AW768, Mouse AW558/AW958/AW959/AW988
1/29/19

5.2.24.0
15 R4, 17 R5, m15, m17, Area-51m
1/22/19

5.2.20.0
15 R4, 17 R5, m15
Windows 10
12/13/18

5.2.17.0
15 R4, 17 R5, m15
Windows 10
11/1/18

5.2.1.0
15 R4, 17 R5
Windows 10
8/17/18

5.2.0.0
15 R4, 17 R5
Windows 10
7/31/18 

5.1.27.0
15 R4, 17 R5
Windows 10
6/7/18

5.1.24.0
15 R4, 17 R5
Windows 10
5/14/18

5.1.18.0
15 R4, 17 R5
Windows 10
4/10/18

5.0.1.0
15 R4, 17 R5
Windows 10
2/14/18

4.7.10.0
13 R3, 15 R3, 17 R4
Windows 10
5/3/17

4.7.7.0
13 R3, 15 R3, 17 R4
Windows 10
9/29/16

4.5.19.1
13 R2, 15 R2, 17R3
Windows 8.1/10
10/27/15

4.5.16.0
13 R2, 15 R2, 17R3
Windows 8.1/10
9/2/15

4.0.54.0
13 R1, 15 R1, 17 R2
Windows 7/8.1
2/4/15

4.0.53.0
13 R1, 15 R1, 17 R2
Windows 7/8.1
1/8/15

3.6.4.0 (Windows 10)
14 R1, 17 R1, 18 R1
Windows 10
1/11/16

3.6.4.0 (Windows 7/8.1)
14 R1, 17 R1, 18 R1
Windows 7/8.1
12/5/14

3.5.14.0
14 R1, 17 R1, 18 R1
Windows 7/8/8.1
12/2/13

3.0.29.0
14 R1, 17 R1, 18 R1
Windows 7/8/8.1
7/5/13

3.0.27.0
14 R1, 17 R1, 18 R1
Windows 7/8
6/11/13

Older MX series

2.8.10.0
M11x R3, M14x R1, M14x R2, M17x R3, M17x R4, M18x R1, M18x R2
Windows 8
2/22/13

2.8.8.0
M11x R3, M14x R1, M14x R2, M17x R3, M17x R4, M18x R1, M18x R2
Windows 7
2/22/13