enabling smb3

Currently we only run SMB versions 1/2 in our Isilon environment, i'm not sure why smb3 was not enabled by default. what are the consequences of turning on  "Support Smb3 Encryption" ? would that cause issues to windows 10/11 clients? my understanding is windows systems will attempt to negotiate to the highest SMB version and will failover to the lower one if there is an issue. 

i did not notice any interruption in connectivty on our simulator and it seems pretty simple to enable/disable smb3 if required, is there meant to be any downtime expected with this?