Brightness and contrast are certainly by user preference, but I have many monitors turned to about 50 brightness while contrast is typically in the 80's to 90's.  Yes, the larger the screen the more "defects" will be seen.  You state the monitor is "crystal clear" so that's a good start.  Fiddle with the settings a bit more.  I think you're on the right track to turn the brightness down.  Now, enjoy!  :smileyhappy: