Take a look at this PowerPath/VE for Vmware performance thread - the report reveals how VMware vSphere 4 performance goes "through the roof" with PowerPath/VE:

http://www.ntpro.nl/blog/archives/1294-Massive-IO-power-increase-using-EMC-PowerPathVE.html

This represents a simple configuration but this posting presents a starting point for a discussion.

What level performance gains are you realizing from Powerpath/VE?