wireless mouse selects ignored until ready

I bought a Dell XPS 9550 in early 2016 with Windows 10 installed. Other than some Microsoft account issues that first year, the laptop has run without issues except for the below wireless mouse issue. The laptop has had all Dell and windows 10 updates since such occurs automatically.  Originally I just used the touchpad but strongly dislike those mechanisms much as I dislike touchscreens.  Note I worked in Silicon Valley decades as a hardware electronics debug tech and test engineer including computer systems especially microprocessors until retiring last year.  

Thus installed a wired USB mouse of which I've used two mice with and it works as expected.  Then I bought a Logitech M187 wireless mini mouse that uses an rf USB dongle as the cable on a wired mouse on laptops tends to get in the way of keyboards.   However it apparently has a firmware low interrupt priority for button clicks to the processor that is not buffered so until other higher priority processes complete and it then allows a USB  mouse click input, I can depress and release the left mouse button repeatedly but it will ignore actuations. The M187 driver is correct and the system acknowledges such. It does not matter what Windows application or window I am using the mouse with though a web browser will delay allowing input longer for operations like loading web pages. The same M187 works normally on my old HP desktop with Windows Vista thus cannot be an M187 issue.  It also acts the same on either XPS USB port and in any physical locations so is not an rf interference issue.  Note mouse XY movements work normally.

I did web research the issue including on the Dell and Logitech sites and have played with all the mouse and usb options in Settings without affect. Nor have I seen help requests for the issue elsewhere thus am here because I just may be missing something. Thus went back to using wired mouse but now am looking at trying to fix the wireless issue again.