Take a look here:

Isilon SDK Info Hub

Thank you Peter Serocka for the helpful documentation on the API.

This heavily depends on what you're trying to do. If you want to write scripts that will interface with the cluster from a remote machine, use Peter's suggestion by taking advantage of the API. If you would like to write scripts that will run on the cluster, you'll need to have an idea of what it is you want to write a script to do in order to figure out if the modules you need to use are available. You can look at the python modules available on any version of OneFS from the python interpreter prompt:

>>> help('modules')

You can then look at the methods/attributes available in any of the modules listed, for example, the io module:

>>> dir('io')

['__add__', '__class__', '__contains__', '__delattr__', '__doc__', '__eq__', '__format__', '__ge__', '__getattribute__', '__getitem__', '__getnewargs__', '__getslice__', '__gt__', '__hash__', '__init__', '__le__', '__len__', '__lt__', '__mod__', '__mul__', '__ne__', '__new__', '__reduce__', '__reduce_ex__', '__repr__', '__rmod__', '__rmul__', '__setattr__', '__sizeof__', '__str__', '__subclasshook__', '_formatter_field_name_split', '_formatter_parser', 'capitalize', 'center', 'count', 'decode', 'encode', 'endswith', 'expandtabs', 'find', 'format', 'index', 'isalnum', 'isalpha', 'isdigit', 'islower', 'isspace', 'istitle', 'isupper', 'join', 'ljust', 'lower', 'lstrip', 'partition', 'replace', 'rfind', 'rindex', 'rjust', 'rpartition', 'rsplit', 'rstrip', 'split', 'splitlines', 'startswith', 'strip', 'swapcase', 'title', 'translate', 'upper', 'zfill']

Alternatively, you can use the inspect module to get more information about a module:

>>> import inspect

>>> for item in inspect.getmembers(io):

...    print item

Further reading on any given python module can be found in the documentation (be sure to use the 2.6 docs):
The Python Standard Library — Python v2.6.9 documentation

OneFS uses 2.6.1, so there will be some slight differences here and there to what is listed in the 2.6.9 documentation.

As with any scripting, it is best to use a virtual machine or test cluster to test anything you write prior to running it on a production machine.