Under 'SMTP Server Name or IP Address' enter the IP address of your email server, just to eliminate the possibly of any unknown DNS issues from interfering.  You can go back later and enter the smtp.something.com FQDN entry later...  Match the mail settings that your server requires in the other fields.  Try your current settings first, but if they fail then you can always try 'Use Default', uncheck 'Use SSL' and 'Everything' on Logging Settings if those first settings fail.  I've seen systems use port 587 as well with Exchange Servers, so may want to try that if you are still having no luck...

For OME SMTP settings, use your SMTP host (e.g., smtp.something.com) as the mail server and enter the full email address (username@something.com) as the username if your mail provider requires authenticated SMTP. Also verify the correct port (25, 465, or 587) and SSL/TLS requirements.

You do not normally need to install a separate Windows SMTP Server role on the OME node. OME can relay mail directly through an existing SMTP server if connectivity and authentication are configured correctly.

For detailed guidance, check the OME documentation for your version. As a user, I also found Getsvision Solutions Pvt. Ltd. – Configure SMTP Support helpful when troubleshooting SMTP configuration issues.

Thank you for your helpful reply