Same problem after updating Win10 this morning....

I haven't tried reinstalling Alienware Sound Center (Realtek-ALC3266-Audio-Driver_HKN2C_WIN_6.0.8699.1_A08\RealtekHDAudio\Nahimic\AWSoundCenter.exe).

I just re-installed the sound driver as stated above. Same thing on re-boot.....NO CHANGE...

Me too. Dozens of popups even without rebooting or logging out. They point to "C:\Program Files\Alienware\AWSoundCenter\UserInterface\x64\AWSoundCenterSvc64.exe", which will eagerly create that popup if you double-click it. Or if you right-click and Run as Admin.

It's not a permissions issue. It's got to be the registry. Dell's support website seems to be down and phone hold time is 45 min, but I'd really like to know if anyone has solved this. It's an old problem (there's a year old thread elsewhere) that apparently has multiple causes.

Same problem after installing latest Windows update.

For me it is because of the Asus Sonic Studio, Just Right click the app and go to properties, compatibility tab and check the "Run as Administrator" it solves for me

You have an Asus app on a Dell computer?

I was facing the same issue on my Alienware r4 17 post the update. There is another workaround this. You can disable the "AWSoundCenter" at startup and that stops the uac asking for permission when you boot the computer.

Thanks...