17 R5, USB Hubs using external HDDs drops out K&M

Hello, I've done a quick search on this forum and only came up with one thread with the suggestion being to update the BIOS, Drivers and check for bus errors. I have done and completed the checks and have no errors.
TL;DR: Using external HDD through a USB 3.0 hub into a side USB 3.0 port drops out the connection to the external mouse and keyboard.
Long version. Purchased an Alienware 17 R5 and received it less than a week ago. Connected it in this manner.
Monitor 1 - ASUS PG278Q ROG SWIFT - Connected via - Alogic 2m Mini DisplayPort to DisplayPort Cable Ver 1.2 - Male to Male - ELEMENTS PN ELMDPDP-02
Monitor 2 - FLATRON L246WHX - Connected via - ALOGIC 2m PRO SERIES High Speed HDMI Cable with Ethernet Ver 2.0 Male to Male HDMI-02- MM-V4B
Right hand side USB 3.0 port connected to Monitor 1 using USB 3.0 Cable. Monitor has 2 USB ports.
Monitor USB 3.0 ports connected to;
ASUS Wired/Wireless ROG Spatha
Cooler Master MasterKeys MK750
Left hand side USB 3.0 port connected to 7 Port TP-Link TL-UH700 USB 3.0 Hub
7 Port TP-Link TL-UH700 USB 3.0 Hub (Has its own power source) connected to; 8TB WD 3.5" USB 3.0 My Book External HDD PN WDBBGB0080HBK (Has its own power source)
Corsair VOID USB Carbon Dolby 7.1 Gaming Headset PN CA-9011130-AP
This was the initial, almost identical setup to my 5+ year old gaming tower. Everything works fine. Except for 2 instances
1) When not using the headphones and trying to use the internal speakers my K&M will intermittently dropout. Using the headphones, no worries.
2) When I go to access the external HDD. Even just viewing the folders in the EXT HDD will intermittently dropout the M&K. Transferring files makes it worse.
So I thought maybe its the hub. I upgraded it to 7 Port Volans VL-HB07 USB 3.0 Hub and kept the same setup. Same issue.
So I though I'll try the rear thunderbolt port and went and bought a 4 Port Volans VL-HB04-C USB-C to USB 3.0 Hub (Has its own power source). The K&M dropout issue stops but the T/B connection randomly drops out. Its like a loose connection yet the connection is solid. I'm at a loss here. Power doesn't seem to be the issue its only when data is being viewed/transferred and the onboard speakers are in use.
Do you think purchasing some headphones to run through the headphone jacks would help lower the load on the USB port? Should I change the USB ports over? Switch to using the left side USB-C some how? Any help would be greatly appreciated.