Unable to create snaphot while backing up a VM using EBRA

ESXi 5.5.0 1331820

vCenter 5.5.0     (Windows 2008 R2 64 bits)

NetWorker 8.1.0.1 (Linux 2.6.32-220.el6.x86_64)

DataDomain DD2500 5.4.6.0-503967 FLC0014250032

EBRA  1.0.0.199

Hi,

While backing up the VMs from a backup group using EBRA, the backup encountered the following event and the backup failed:

Event Details:

  Type: info

Time: 10/29/2017 10:04:34 PM

Task Details:

  Name: CreateSnapshot_Task

Description: Create virtual machine snapshot

Error Stack:

   An error occurred while taking a snapshot: msg.fileio.generic.

Unable to retrieve the current working directory: 2 (No such file or directory). Check if the directory has been deleted or unmounted.

Unable to retrieve the current working directory: 2 (No such file or directory). Check if the directory has been deleted or unmounted.

Unable to retrieve the current working directory: 2 (No such file or directory). Check if the directory has been deleted or unmounted.

Additional Event Details:

  Type ID: Info

Target Object Type: ClusterComputeResource

DataCenter Object Type: Datacenter

Host Object Type: HostSystem

Host Build: 1331820

VirtualMachine Object Type: VirtualMachine

ChainId: 7079812

Additional Task Details:

  VC Build: 1312298

Task Id: Task

Cancelable: False

Cancelled: False

Description Id: VirtualMachine.createSnapshot

Event Chain Id: 7079812

It seems that setting the disk.EnableUUID (KB 2079220/ https://kb.vmware.com/s/article/2079220 )to false and reboot the VM fixed the problem.  But later on, we found that without the change, rebooting the VM also fixed the above problem.

What could be the correct solution and is there a solution avoiding rebooting the VM?