Moving over windows shares and ntfs perms

Ok a little confused on something. So looking at moving over various windows shares currently on 2008 and 2012 boxes. Almost all of them have access granted via AD groups. Some dept shares have subfolders that are not shares where inheritance is turned off and access to that is granted via another AD group. So the dept generates the data and outside users are able to access that particular folder.

Typically all our shares uses the same AD groups for both the share and ntfs permissions and ABE is set on all shares. When I look in OneFS I get that I need to 1st create the folder under file system explorer then go to protocols and create the share. I can then add the same AD groups to the share side there.

My question though is really about the equivalent ntfs side. On all our shares now, some have inheritance off, and Everyone, Domain users etc are all removed. Domain Admins is added along with the various AD groups. For the Isilon, would I do the same thing by going to like \\isiview1\ifs\data\isidata\Depts~ and then managing my various folders permissions on the security tab like in windows? Ive tested on one share and seems to work fine.

I turned off inheritance under advanced and removed the items I didn't want, added those I did. The for any subfolders within that where only certain users need access I repeated.

Is this correct?

thx