Use SyncIQ.

https://www.dellemc.com/resources/en-us/asset/white-papers/products/storage/h8224_replication_isilon_synciq_wp.pdf

page 52

Same when using external backup tools that leverage NDMP 

https://support.emc.com/docu90415_Isilon-OneFS-8.1.2-Backup-and-Recovery-Guide.pdf

see Chapter 'NDMP backup and restore of cloud data' on page 70

OneFS 8.2 adds even more options and control, see

https://community.emc.com/community/products/isilon/blog/2019/09/05/onefs-ndmp-enhancements

hth

-- Peter

thanks, Phil and Peter for quick response.

I will go through the same and get back in case need some assistance.

Appreciate it!