Have a look at the following EMC Hadoop Starter Kit (HSK):

https://community.emc.com/docs/DOC-26892

Here is a white paper:

http://www.emc.com/collateral/software/white-papers/h10528-wp-hadoop-on-isilon.pdf

There is also the OneFS Administration/User Guide which has some detail on the actual configuration required on the Isilon.  You can jump to the chapter dedicated to Hadoop:

v7.x

https://support.emc.com/search/?resource=DOC_LIB&AlloftheseWrds=onefs%20administration%20guide&SearchWithin=true&adv=y

< v7.x

https://support.emc.com/search/?resource=DOC_LIB&AlloftheseWrds=onefs%20user%20guide&SearchWithin=true&adv=y

EDIT (09/29/2013): Cleaned up formatting

Below link was very useful for me to understand HADOOP.

https://community.emc.com/docs/DOC-26892

Can you give me link for same kind of doc for ISCSI & FTP? as i already gone through administration guide but facing some challenge.