U2720Q, eye strain, #2

Response from Kristoffer71 is incorrect. You cannot change spectral power distribution of a display, it's a property of its backlight and these Dells use no different backlight tech than others, since there are a few LED + panel manufacturers, all using WLED PFS phosphor or QLED variants for current wide gamut LED sources.
sRGB mode only simulates primaries by mixing native primaries. Resulting spectral distribution is the same as it would be using native gamut presets while showing sRGB image in photoshop, or all in gamut colors (in sRGB) of any P3, AdobeRGB or ProPhotoRGB image while in native gamut OSD presets.

If you have eye strain make sure:
-using native resolution
-Scale UI from your OS to a suitable size, at least 150% for typical Windows setups. Feel free to scale to 200% if it looks too small for your vision
-use 60Hz... if not 60Hz then you have a setup issue in your GPU configuration
-LOWER BRIGHTNESS until matching your other displays.
AFAIK this display should not use slow PWM brightness regulation, so there should be no issue.

Here are my settings right now, and I am still getting eye strain from this monitor. Is there any suggestions on what to try to change/experiment with?

Windows 11 -

Size of text, apps, and other items: 300% (Recommended)

Display resolution: 3840 x 2160

Display orientation: Landscape

Let Windows try to fix apps so they're not blurry: On

Night light: Off

Monitor-specific:

Brightness: 40%

Contrast: 40%

Preset Mode: Comfort View

Input Color Format: RGB

Aspect Ratio: Wide 16:9

Sharpness: 100

Response Time: Fast

Smart HDR: Off

Usually in preset Standard or Custom color mode

-Contrast: default value ad DO NOT change it
-Brightness may vary between models but usually 120-160nit range should be in 20-30% range of brightness slider. Depending on ambient light you may need more or not.

muaaman,

Have you tried changing the settings to see if they will help?