Yes, it is possible to integrate Dell Command Update (DCU) with Microsoft Endpoint Configuration Manager (MECM). Here are some general steps to follow:

1. Download the DCU command-line interface (CLI) executable from the Dell website.
2. Create a package in MECM that includes the DCU CLI executable and any necessary supporting files.
3. Create a program within the package that runs the DCU CLI executable with any desired command-line arguments.
4. Deploy the package to the desired collection(s) of devices in MECM.
5. Monitor the deployment status and results in the MECM console.