Connection Failed

Hi
Wondering if I can have some help with this problem.

Running Windows 7 Pro 64 Bit and have a Sensation with ICS. Since the ICS update I get the Connection Failed message and despite repeated attempts to connect to my PC I cannot. However, if I connect wirelessly I can connect and subsequent attempts to connect non wirelessly are successful until I restart the phone.

I am baffled.

Thanks for any help an assistance