Props for getting 850w PS and using DP interface for monitor and wired Ethernet.

Check Event Viewer for exact error message... it's likely telling you what is wrong.

Is Device Manager free of errors?

What video card driver are you using, and have you tried "clean-installing" it.

Hey, in DeviceManager ... is it showing AMD (dedicated) card AND an Intel (on-board) video card?

Device manager had an error on the "AMD high Def Audio Device" but I corrected that so now no errors.  Still same problem with browser freezing and crashing, unrecoverable.  

Display drivers showed "Intel HD Graphics 530" AND "Radeon RX 480 Graphics", so I  disabled the intel driver.  Same issue still.

Original AMD Radeon RX 480 driver v21.19.137.1, updated Driver via Windows to v16.200.1035.0 just now will see what happens.

Event viewer of most recent browser failure is as follow (while running v21.19.137.1):  

"

The application-specific permission settings do not grant Local Activation permission for the COM Server application with CLSID

{9E175B6D-F52A-11D8-B9A5-505054503030}

and APPID

{9E175B9C-F52A-11D8-B9A5-505054503030}

to the user DESKTOP-8589AGO\ChrisP SID (S-1-5-21-4109068468-2096406173-1797789379-1001) from address LocalHost (Using LRPC) running in the application container Microsoft.MicrosoftEdge_38.14393.0.0_neutral__8wekyb3d8bbwe SID (S-1-15-2-3624051433-2125758914-1423191267-1740899205-1073925389-3782572162-737981194). This security permission can be modified using the Component Services administrative tool.

"

Not 100% sure what to do with this... Any thoughts?

I will restart and see what happens with "new" old version AMD driver.

I have 3 Logitech mice

Try with just one mouse.

1. Display drivers showed "Intel HD Graphics 530" AND "Radeon RX 480 Graphics", so I  disabled the intel driver.  Same issue still.   2. Original AMD Radeon RX 480 driver v21.19.137.1, updated Driver via Windows to v16.200.1035.0 just now will see what happens.   3. Event viewer of most recent browser failure is as follow (while running v21.19.137.1):

1. See if you can disable the on-board Intel video from BIOS.

2. Yes, good to try both the Windows (suggested or given) Windows Update driver and then the latest AMD release driver for RX-480 (but separately) . Are you familiar with proper video driver "clean install" procedures?

3. Hmm. Yes, that might be Edge browser crashing. I wonder if something like this might provide more info as to the cause.

http://www.nirsoft.net/utils/application_crash_report.html

http://www.nirsoft.net/utils/blue_screen_view.html

http://www.resplendence.com/whocrashed

Original AMD Radeon RX 480 driver v21.19.137.1, updated Driver via Windows to v16.200.1035.0 just now   I will restart and see what happens with "new" old version AMD driver.

While that driver appears to be much older (and it might actually be) ... remember that there are various driver types (2D, 3D, etc.) and also a Package  ... all of which have "driver versions". Sometimes it's hard to compare "apples to apples".

In addition to the Windows and AMD.com drivers for this card, Dell might also have a validated driver posted (might be tweaked in some way).

Well it's working now after just letting Win10 update drivers to its version v16.200.1035.0.  I'll leave it this way for a while to see if stable.  Fingers crossed.  I did not clean install yet but will try that in a few weeks with the AMD.com driver(s) if I find any issues.  Thanks!  The browser freeze/crash was in all 3 I have installed, ie11, edge and chrome.

Well it's working now after just letting Win10 update drivers to its version v16.200.1035.0.

Good work.