Here is an update:

I contact the dell support via phone call.

They helped me reinstalled some drivers. However, the issue still exist.

The support has contacted the engineering team and they are working on the problem.

Here is another update.

The support helped me reinstalled Windows, and have all the drivers installed and updated.

However, the problem still remains.

The support contacted the engineering team, and they are able to reproduce this issue.

The keyboard and mouse that are not affacted is Alienware keyboard and mouse, the 3rd party keyboard and mouse seems have this issue.

They believe this is a driver issue, that exists in the Alienware Command Center, and they are working on a fix.

Hello, 

For my notes, click my Alienware-name and private message me the Alienware PC service tag number.

I haveeeeeeeeeeeeeeeeeee this issue too,  see? I'm nnnnnnnnnnnnnnnnnnnnot kiiiiiiiiiiiiiiiiiiidding.  is there a fix?

I am disaaaaaaablin g stttttttttttttartuppps aaaaaaaaaaaaapp[s nnnnnnnnnnnnnnnnnnnnow, when windows first boots the mouse works for about 30 seconds, then it fails and stutters constantly, this right here is the best its ran in days. which isn't saying much. 

just updteeeeeeeeeeeeeeeeeedddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddddd firmware                      still happening.                   mouse lags too. have triiiiiiiiiiiiiiiiiied uuuuuuuuuuuuuuuuuuuuuuusing    both USSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSB ports n nd fiiiiiiiiiiiiiiiiiiireeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeewire port with                    and wwwwwwwwithout hubbbbbbbbbbbbbbbbbb.

and I rrrrrrrrrrrrrrrrrun support asssist naaaaaaaaaaaaaaad do a testtt on the mouse and keyboard annnnnnnnnnnnnnnnnnnnnnnnnnnd  thy wwwwwwwwwwwwwwwwworrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrk finnnnnnne. annnnnnnnnnnnnnnnnnoying,