I wonder if anybody has ever solved this issue.  I have a 980 MT I run 8 x 2 GB memory with no issues.  According to specs the machine will handle 4 x 4GB in a 64 bit enviroment.  I started out with 4 x 4 of 1600 DDR3 memory that everybody said would work through backwards compatibility.  No go.  Arrived at BIOS and memory was populated, but machine never booted or completed repairs.  It just gave me messages such as Kernel Security Check Failure on the ole BSOD and restarted over and over.  I contacted G.Skill and was told I would have to get the 1333 memory, which I did, but still the same issue.  It's definitely looking like this just can't be done and apparently others have arrived at the same conclusion, contrary to posted online specs.

Additional info:  my CPU is the Intel i5-650 and a look at the Intel site also indicates 16 GB capable of DDR3 1066/1333

I am in the process of maybe answering my own question.  Not being a memory expert I have not noticed the distinction between the PC3-10600 4 x 2 GB ram I'm running with no issues in my machine and the memory PC3-1066 memory that the Intel site says this processor will support up to 16 GB. There is apparently a difference, but I'm kind of afraid to try any more new memory that I might have to also find a way to sell.  From what I have discovered my existing memory runs at 1333 MHz but the other memory runs at 1066 MHz, so you have to wonder if 16 GB at the lower frequency will make for a more capable machine than 8 GB at the higher frequency.  Boy, am I confused.