I'm new to EMC in general and starting to look into Isilon as storage for HDP.
Does the Isilon simulator support integration w/ HDFS and Kerberos?
Yes you can download the simulator and configure it up with HDFS and Kerberos.
The simulator is the best way to build a proof of concept, test out your policies, tiering, etc.
Make sure to use the following HDFS focused thread to help answer your questions you might run into.
Using Hadoop with Isilon - Isilon Info Hub