I know that some displays have a configurable setting to determine whether the USB data path remains active even while the display is asleep, so you might have to configure that, but not reactivating when the display wakes back up does sound strange.  However, if you find that setting to keep USB active even while the display is asleep, that might work around a potential bug about it not reactivating when the display wakes back up, since now the USB data path won't go inactive in the first place.

Thanks for your reply @jphughan however changing display settings didn't help. I have set up next options as ON "USB-C Charging - On During Power off" and "USB-A Charging - On During Standby" but it doesn't solve the issue with the "Power Save Mode".