Thank you for replying to this.  I am glad I am not the only one (I figured I wasn't), and glad that other people are agreeing/commenting on this issue.  Hopefully we can get some type of reply from Dell, as this is a big problem, and it is affecting numerous people.

This has been an issues for several months. When is Dell going to resolve????

 Running into the same issues

In my case the Webroot AV agent and Add-On needed to be disabled.

FYI, I opened a case with Dell, they helped me troubleshoot. They also indicated the following

1. They are trying to integrate everything into SupportAssist via the web.
2. They have a standalone SupportAssist Agent as well. 
   1. http://www.dell.com/support/contents/us/en/04/article/product-support/self-support-knowledgebase/software-and-downloads/supportassist

@SupportAssistissues

Yup, the full Win10 install was my last resort, and failed.

Thanks for your suggestion, and I actually tried that already.

Sadly, I would still have to download each driver and application manually, as the Dell's website refuses to recognize that I do in fact got SupportAssist installed and running on my computer.

Sad and busy day today....

@Doug218

That sounds absolutely horrible. I hope it doesn't come to a full Windows re-install.

What I have been trying is installing the full SupportAssist program, and using it to download and install drivers.  After I am done I uninstall it because it kills disk usage when it runs, which seems at least every time you log in.  I am not sure if Alienware works the same as Dell, but if you are using Dell to install the drivers/firmware, it may.  I am not sure if it works as well, but at least it may get some critical drivers/firmware installed.

The link to download it is below.  Try installing that, then run the driver scan.  Hopefully that helps you.

http://www.dell.com/support/contents/us/en/04/article/product-support/self-support-knowledgebase/software-and-downloads/supportassist

@tdward

Thanks for the info.  I was thinking it may have been AV, but it is even failing on new installs. I have tried IE and Edge, which are default installed with Windows.  I don't lower any security within the browsers, but they also don't have any add-ons.

Did they tell you if they are moving all the functionality of the web into SupportAssist, or working on getting SupportAssist to work better with the website?

I thought I had gone mad, 'cause seems all of the sudden nothing at all works and I thought it was just me.

I guess I'm glad in a way that I'm not the only one running into this.

But then again, really disappointed to see issues like this. Espectially I ended up recovering my laptop from an "Urgent" Bios update that killed my laptop's shutdown / sleep / restart function, along with messing up a "TPM" device.

Now I'm stuck with a laptop that won't shutdown / sleep / restart, and missing all of Alienware's software / drivers.

What I did to deserve all these?

@Doug218

That is a real pain. That's way too bad that you had to do each one individually. I really hope they come out with some type of fix. Considering this is an industry standard method of updating manufacturer specific drivers/firmware (HP has the same type of thing).  I have already seen some people posting that they are recommending people against Dell just due to this alone. I love Dell, I have for a long time, but I am currently in the same boat. There is no way I would recommend Dell to anyone, and I work in IT, where my opinions counts on what is purchased.  I hope Dell fixes this soon, I love Dell's but this is a major pain to deal with.

Ha! I just posted a reply summarizing the problem as I see it and it looks like someone deleted it.

So I'll stick to dry facts. SupportAssist stopped working on my computer and made it very unstable. I tried uninstalling all antivirus, firewalls, and backup programs. SupportAssist would not even let me install it or uninstall it. I went back to a Windows restore point and immediately deleted all Dell software and now the computer works beautifully. I am disappointed because I really liked the SupportAssist software. Now what I have is basically the equivalent of a build-your-own Windows PC. I have one of those and it just keeps getting better with the Windows updates. The changes I can see that happened since the restore point are that the SupportAssist software appeared to add a plug-in for an antivirus upsell and the April 10 Windows 10 update. I can't recommend Dell computers until they fix this critical error. I think the situation is so convoluted that I could never solve the problem on my own without deleting all Dell software. There, that's cut and dry and purely factual and hopefully will be helpful to someone, either in their decision as to whether to buy a Dell computer at this time or how to fix the problem--go back to a restore point and delete all Dell software as fast as you can. We'll see if the post survives. If not, there's always social media. : )

I just tried to call Dell support about this SupportAssist problem and after I waited on the line for 10 minutes the representative told me he had to transfer me to the XPS department and the recording said the wait was 45 minutes or more. So I would guess this is a major problem. I will try the online chat if they have it.

For those of you who, like me, cannot get SupportAssist to work on your computer anymore, Lifewire (owned by NYTimes, IIRC) has a great article listing 10 free driver updater programs. I downloaded one of the programs and it updated 12 older drivers on my computer and all is well. This of course does what SupportAssist is supposed to do, but without the instability or risk to your computer's health. Malwarebytes and Windows Defender both say all is well after the updates. I'll uninstall the free updater just to be safe.

@SupportAssistissues

I, myself, also work in the IT field and agree that I would not recommend Dell to anyone until they got the issues settled.

The recent events I encountered with this Alienware suggest to me that someone seems to be slacking in testing prior to a public release, and I do not feel such practice is acceptable.

Anyway I finally gathered and installed all of the drivers, I guess I should be glad that downloading them 1 by 1 still works.