Error Message - The Operating System is presently not configured to run this application

I just recently bought Dell XPS 8900 with Windows 10 installed.  I installed couple of applications including Security software, MS Office 2016, Adobe Light Room. The computer came with a solid state drive configured as Drive C.  When I first installed software it automatically installed on the solid state drive which quickly filled up.  Then I was told to install the Office-365 on the Hard Drive configured as Drive I. So I uninstalled Office, and reinstalled it on Drive I.  Somewhere along this, I started getting this error message "The Operating System is presently not configured to run this application".  Also, it seems that the performance of brand new computer has slowed down a bit.  What is going on?  What did I do wrong?  Can you please help fixing this?