Long time reader, first time poster.

I'm having a strange issue with Precision 5510's (posted this under XPS since it was the closest available forum, apologies) where after installing Windows 10, the M.2 NVMe SSD will randomly disappear from the system, giving us a "no boot device found" error.  If you go into the BIOS when this happens the drive will not be listed there.  It doesn't happen all of our machines, probably about a third of them and it's inconsistent; you can boot the machine 10 times and out of that 2 times it will see the drive and boot just fine.

These machines have the M.2 NVMe drives, which we're using as the primary drive for the OS, and they also have an additional SATA SSD being used as a data drive.  I did just find this: http://www.dell.com/support/article/us/en/19/sln301036/windows-10-install-with-nvme-ssd-and-sata-drives?lang=en, which is the closest thing I can find relating to our issue, but isn't exactly what we're experiencing and I haven't tried the workaround yet.

For installing Windows 10 we're pxe booting and installing an image using Ivanti.  I'm not privy to all of the details of that environment.

Up to this point we'd open a ticket with Dell support, they would come out and replace the MOBO and that would resolve it.  All the signs point to hardware issues to me but I find it hard to believe that all of these machines keep having the same hardware issue, especially when many of these machines had been running just fine for a year or more when they were on Windows 7.  I've not seen the issue occur on the same machine again after the MOBO replacement.

Those are all of the details I can think of at the moment, but I'm sure someone will think of something I neglected to detail.

Has anyone run into this before?  Any ideas what could be happening?  Much appreciated.

-Stefan