First of all there are many index.dat files that windows creates. Why do you want to delete "Index DAT file"? Please provide more info.

Cleaning your history does not clean the index.dat files. You can use the procedure listed in this URL:

http://www.tweakxp.com/article37372.aspx 

Message Edited by delta7000 on 10-24-2005 10:57 AM

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@delta7000 wrote:

Cleaning your history does not clean the index.dat files. You can use the procedure listed in this URL:

http://www.tweakxp.com/article37372.aspx 

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You might want to think twice before applying the fix in that link. It states it will remove all the index.dat files. If it happens to remove the index.dat file for
PCHEALTH, your System Information (msinfo32) tool will be crippled.

http://www.xpbanter.com/showthread.php?t=9531&page=3 

(Scroll down in that link to message#25 by Wesley Vogel.)

joe 53 is correct. If you're intent on removing your index.dat files you need to make that one a read only file before you clean them. To do that do the following: click on start and then double click on  my computer, your hard drive(local disk), the windows folder. Scroll down to the PCHEALTH folder and  double click on that. Then double click on HELPCTR and then OfflineCache. Right click on the index.dat file and click on properties. Check the box that says read-only and then click on apply and ok. The procedure outlined in TweakXP will delete all index.dat files except that one. After deleting the files go back and remove the check.