The following is an indication of a virus
O4 - HKLM\..\Run: [Microsoft IIS] C:\WINDOWS\system32\syshost.exe
Click on the following link for repair details:
http://securityresponse.symantec.com/avcenter/venc/data/w32.francette.worm.html

The following is a RapidBlaster Infection:
O4 - HKLM\..\Run: [rb32 ml710e] "C:\Program Files\RapidBlaster\rb32.exe"
Download RapidBlaser Killer her http://www.wilderssecurity.net/downloads/rbkiller.exe to fix that.

Delete the following entries in HijackThis:
O4 - HKCU\..\Run: [Microsoft IIS] C:\WINDOWS\system32\syshost.exe
O4 - HKCU\..\Run: [Microsoft IIS] C:\WINDOWS\system32\syshost.exe
O4 - HKLM\..\Run: [rb32 ml710e] "C:\Program Files\RapidBlaster\rb32.exe"

Optionally delete the following entries as they are resource hogs - NOT Spyware:
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Microsoft Office\Office10\OSA.EXE

Please repost a new log after you have cleaned this up and rebooted your computer.

is there any order that i should do this in?

Do it in the order shown - do a reboot between each stage - it is good advice.