Hi Ferdy,

Since when you are facing this issue?
Do you get any error message when you open Internet Explorer?
May I know the operating system installed on your computer? 

Since it works in Safe Mode, you may try the following steps.

Reset the Internet Explorer settings:

• Close any ‘Internet Explorer’ or ‘Windows Explorer’ windows that are currently open
• Open ‘Internet Explorer’
• Click the ‘Tools’ button,
• Click ‘Internet Options’
• Click the ‘Advanced’ tab, and then click ‘Reset’
• Select the ‘Delete personal settings’ check box if you would like to remove browsing history, search providers, Accelerators, home pages, and InPrivate Filtering data
• In the Reset Internet Explorer Settings dialog box, click ‘Reset’
• When Internet Explorer finishes applying default settings, click ‘Close’
• Click ‘OK’
• Reopen ‘Internet Explorer’ and check

Alternatively, you may perform System restore. Here are the steps:

• Click on 'Start'
• Click on 'All Programs' then click 'Accessories'
• Click on 'System Tools'
• Click on the 'System Restore'
• Then click 'Next' on the "Restore system files and settings" window
• Then choose the restore point that you want to use(choose a date when the system was working good)
• After that click 'next' to continue
• Then click 'Finish' on the "Confirm your restore point" window to start the System Restore
• Then Click 'Yes' to the once started, System Restore cannot be interrupted. Do you want to continue? dialog box.
• System Restore will now restore Windows 7 to the state that was recorded in the restore point.
• Immediately after logging in to Windows 7 after the reboot, you should see a message that System Restore completed successfully
• Click 'Close'
• Restart the computer and check

You may refer to the link for more information on System Restore http://dell.to/VRG2ad

Please reply if you have any questions.