Yes I do.

On a regular basis I run RegistryMedic from Iomatic and now I start with Registry mechanic from PcTools.

Alas...very poor results.

Have you checked in msconfig to see what is running every time you boot up?  You should only have a few entries checked in there

 

Start/Run and type in
msconfig
OK

Startup Tab
Keep the page open then go to one of the links below. They will tell you what all the entries are and whether you can disable them or not. They will also identify any malware.  Disable everything which is not needed to run at start up

http://www.sysinfo.org/startuplist.php

http://www.castlecops.com/StartupList.html

Read the Key at top of page. Use the Search box to check all your entries

 

When you reboot you will get a message saying you have started in "Selective Startup"  Click "Don`t show this message again" then OK