So I have the most annoying problem with an R16 and it revolves around USB ports. There are two main issues that are common. 

The first is that occasionally, not always, the R16 gets to a black boot screen, no beep codes, no Alienware logo. 

In order to boot properly, I have to unplug at least the keyboard (front USB port) and sometimes every USB device. That causes a no keyboard error, and then the system boots. 

I then plug everything back in (same ports) and it boots fine for a few boots. 

I always shutdown completely. I have tried turning off sleep and hibernate, keeping power on on everything in Windows i.e. no sleeping USB for example (I don't mind full performance always so that's not a problem). 

Its random, and might be down to the amount of time the R16 is switched off. I haven't debugged it that much.  But the Keyboard out (and then sometimes all other devices) is the way to get my system to boot properly.

Maybe connected is problem number 2. The USB-C ports at the back don't work well with USB C devices, but the front port does. It's only on devices that have a specific power need and/or are very chatty in bandwidth. This is directly plugged in. As far as I am concerned, there should be NO behavior difference but there is. Example Native Instruments Kontrol Keyboard. Works fine on the front port, back ports it has a very hard time behaving consistently.  

My concern is that the drivers/firmware for the USB is not very reliable. As the two are quite different problems in a sense, but they point to a software issue not a hardware issue. When the system is up and working, everything is fine USB wise for example for 2.0 devices. 

I've tried moving devices around (within what I can) and avoiding hubs. Unfortunately I need some hubs for low bandwidth devices like Midi Keyboards.

I have checked the Administration Logs and there are no obvious USB issues and/or critical boot errors. As I said on boot it doesn't even get to the Alienware logo.