I sort of understand the need to integrate the Fn keys with some other keys but a problem comes up when I want F10-F12 to behave as Home, End, Prt Sc while other Fn keys just be the regular Fns. How can I do that?

This design dramatically slows you down when using Excel, you can't press F2 to edit while having to ability to use control + home/end very quickly. Who would press Fn or Fn + Esc to switch that often??

Any way I can configure the keys individually?