Access is denied. (Win32 error 0x5) in Networker 8.2

Hi Friends,

We are getting backup failures with error Access is denied. (Win32 error 0x5).

Below are our setup details,

Networker server 8.2.3.8 running on Windows server 2012 R2

Client servers are on windows server OS.

The backups of some client servers failing with the below error's,

5191:save: File E:\AdminOnly\Windows 10 ADMX\Windows10-ADMX.msi could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

5191:save: File E:\AdminOnly\Windows8.1-KB2966828-x64.msu could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

File C:\Windows\ccmcache\8a\windows8.1-kb3148198-x64.cab could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

File C:\Oracle\product\11.2.0\client_1\jre\1.5.0\lib\rt.jar could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

File E:\DPW\Interchange_dpw_2.4.2.zip could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

File C:\Windows\Installer\104d9cff.msp could not be opened and was not backed up. (Access is denied. (Win32 error 0x5))

Please suggest,

thanks in advance.