I have a Windows 10 image, created by ImageAssist version 5.9.0.0 on a flash drive. 

After clicking on the Image Restore function In Image Assist on an Optiplex 5080, I get an error "Disk 0 is main running drive, and there is no disk 1. Process can't continue. Please run this tool again from a different drive."

The same flash drive has no issues imaging an Optiplex 5050.

I noticed that the 5050 and 5080 were installed on Sata-1 and Sata-3 respectively. I switched the dvd drive to Sata-1 on the 5080. Same error.