When you install Alienware Command Center from the AWCC installer (setup.exe) and other Microsoft applications open or running in the background, you may receive a 1603 Installation Error message, and the installation will fail.
This error happens on systems running Windows 10 version 1709 or higher.
Supported Systems: All Alienware Systems
This error comes up because there are shared files needed for installation that are in use by other UWP (Universal Windows Platform) apps causing the installation to fail.
Install the latest version of the Alienware Command Center. For more information refer to Dell Knowledge base article How to Remove and Reinstall the Alienware Command Center.
Here are some recommended articles related to this topic that might be of interest to you.