Isilon: Error 18 at 0 depth lookup during Encrypted SyncIQ configuration

While setting up Encrypted SyncIQ, you receive the following message during the csr validation step:

# openssl verify -CAfile ca.pem source.pem
source.pem: C = US, ST = CA, L = xxxx, O = xxxx, OU = PS, CN = xxxx, emailAddress = xxx@xxx.com
error 18 at 0 depth lookup:self signed certificate
OK

This indicates that at 0 depth (that is the top of the signer tree), it discovered a self-signed certificate, but this certificate was not trusted. Since OpenSSL cannot verify any of the signers of the certificate, it cannot verify the certificate. Since this is a fatal problem, it produces the above error.

The most common cause:

You answered the question identically for the Common Name used in CA self-signed .csr and the current .csr you have generated.

When running openssl req -new -newkey there must be some variation between the Common name field when generating the CA certificate versus the source/target certificates. The following field cannot be identical between .csr's:
 

Common Name (e.g. server FQDN or YOUR name) []: